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Gene and stem cell therapy for erectile dysfunction.

W Deng·T J Bivalacqua·W J G Hellstrom·P J Kadowitz
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Abstract

Erectile dysfunction (ED) is defined as the inability to attain and/or maintain penile erection sufficient for satisfactory sexual performance. ED is a highly prevalent health problem with considerable impact on the quality of life of men and their partners. Although the treatment of ED with oral phosphodiesterase type V (PDE5) inhibitors is effective in a wide range of individuals, it is not efficacious in all patients. The failure of PDE5 inhibitors happens mainly in men with diabetes, non-nerve sparing radical prostatectomy, and high disease severity. Therefore, improved therapies based on a better understanding of the fundamental issues in erectile physiology and pathophysiology have recently been proposed. Here, we summarize studies on ED treatment using gene and stem cell therapies. Adenoviral-mediated intracavernosal transfer of therapeutic genes, such as endothelial nitric oxide synthase (eNOS), calcitonin gene-related peptide (CGRP), superoxide dismutase (SOD), and RhoA/Rho kinase and mesenchymal stem cell-based cell and gene therapy strategy for the treatment of age- and diabetes-related ED are the focus of this review.

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AnimalsCalcitonin Gene-Related PeptideErectile DysfunctionFemaleGenetic TherapyMaleMesenchymal Stem Cell TransplantationNitric Oxide Synthase Type IIIStem CellsSuperoxide DismutaserhoA GTP-Binding ProteinJournal ArticleReview

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W Deng, T J Bivalacqua, W J G Hellstrom, P J Kadowitz. 2005. Gene and stem cell therapy for erectile dysfunction.. https://doi.org/10.1038/sj.ijir.3901430

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