PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 16395131

Could blue light-blocking lenses decrease the risk of age-related macular degeneration?

Carolyn Glazer-Hockstein·Joshua L Dunaief
View original source ↗Export metadata ↓

Abstract

Epidemiologic and experimental evidence suggests that blue light-blocking lenses could theoretically benefit patients with age-related macular degeneration. Clinical trials are needed to determine the effect of yellow lenses in preventing the progression of age-related macular degeneration.

Explore related subjects

Disease ProgressionEyeglassesHumansLightMacular DegenerationRisk FactorsEditorial

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Carolyn Glazer-Hockstein, Joshua L Dunaief. 2006. Could blue light-blocking lenses decrease the risk of age-related macular degeneration?. https://doi.org/10.1097/00006982-200601000-00001

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival.

BACKGROUND: Increased expression of Eph receptor tyrosine kinases and their ephrin ligands has been implicated in tumor progression in a number of malignancies. This report describes aberrant expression of these genes in ovarian cancer, the commonest cause of death amongst gynaecological malignancies. METHODS: Eph and ephrin expression was determined using quantitative real time RT-PCR. Correlation of gene expression was measured using Spearman's rho statistic. Survival was analysed using log-rank analysis and (was visualised by) Kaplan-Meier survival curves. RESULTS: Greater than 10 fold over-expression of EphA1 and a more modest over-expression of EphA2 were observed in partially overlapping subsets of tumors. Over-expression of EphA1 strongly correlated (r = 0.801; p < 0.01) with the high affinity ligand ephrin A1. A similar trend was observed between EphA2 and ephrin A1 (r = 0.387; p = 0.06). A striking correlation of both ephrin A1 and ephrin A5 expression with poor survival (r = -0.470; p = 0.02 and r = -0.562; p < 0.01) was observed. Intriguingly, there was no correlation between survival and other clinical parameters or Eph expression. CONCLUSION: These data imply that increased levels of ephrins A1 and A5 in the presence of high expression of Ephs A1 and A2 lead to a more aggressive tumor phenotype. The known functions of Eph/ephrin signalling in cell de-adhesion and movement may explain the observed correlation of ephrin expression with poor prognosis.

Disease Progression↗