Mouse macrophages contain a truncated CD4 transcript.

S C Moore; S J Anderson; W S Walker

doi:10.1002/jlb.52.1.128

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Mouse macrophages contain a truncated CD4 transcript.

S C Moore·S J Anderson·W S Walker

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Abstract

Mouse macrophages do not express CD4 on their surfaces. We used the polymerase chain reaction to investigate CD4 gene transcription in individual clones of primary mouse splenic macrophages and cell lines of spleen and bone marrow macrophages. The results show only the presence of CD4 mRNA transcripts that are truncated in the 3' coding sequence, thus explaining the lack of expression of a mature CD4 gene product by these cells.

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Animals Base Sequence CD4 Antigens Exons Macrophages Mice Molecular Sequence Data Polymerase Chain Reaction Transcription, Genetic Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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S C Moore, S J Anderson, W S Walker. 1992. Mouse macrophages contain a truncated CD4 transcript.. https://doi.org/10.1002/jlb.52.1.128

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