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PubMed · 16402101

Agonist-activated ion channels.

David Colquhoun
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Abstract

This paper looks at ion channels as an example of the pharmacologist's stock in trade, the action of an agonist on a receptor to produce a response. Looked at in this way, ion channels have been helpful because they are still the only system which is simple enough for quantitative investigation of transduction mechanisms. A short history is given of attempts to elucidate what happens between the time when agonist first binds, and the time when the channel opens.

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AnimalsHistory, 20th CenturyHistory, 21st CenturyHumansIon Channel GatingIon ChannelsLigandsHistorical ArticleJournal ArticleReview

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BibTeXRIS

David Colquhoun. 2006. Agonist-activated ion channels.. https://doi.org/10.1038/sj.bjp.0706502

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