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PubMed · 16405364

Oral clefts with associated anomalies: methodological issues.

Diego F Wyszynski·Andrea Sárközi·Andrew E Czeizel
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Abstract

OBJECTIVE: To discuss methodological factors that account for the wide variation in the reported prevalence rates of anomalies associated with oral clefts. CONCLUSIONS: The published prevalences of associated anomalies vary considerably because of the following: (1) differences in case definition and inclusion/exclusion criteria; (2) length of time after birth that cases are examined; (3) variability of clinical expression of associated anomalies; (4) knowledge and technology available to produce syndrome delineation; (5) selection of patients, sources of ascertainment, and sample size; and (6) true population differences and changes in frequency over time.

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BiasCleft LipCleft PalateCongenital AbnormalitiesEpidemiologic MethodsHumansMedical Laboratory SciencePatient SelectionPenetrancePrevalenceSample SizeSyndromeTime FactorsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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BibTeXRIS

Diego F Wyszynski, Andrea Sárközi, Andrew E Czeizel. 2006. Oral clefts with associated anomalies: methodological issues.. https://doi.org/10.1597/04-085r2.1

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