Structure and function of matrix metalloproteinases and TIMPs.

Hideaki Nagase; Robert Visse; Gillian Murphy

doi:10.1016/j.cardiores.2005.12.002

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Structure and function of matrix metalloproteinases and TIMPs.

Hideaki Nagase·Robert Visse·Gillian Murphy

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Abstract

Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. They play central roles in morphogenesis, wound healing, tissue repair and remodelling in response to injury, e.g. after myocardial infarction, and in progression of diseases such as atheroma, arthritis, cancer and chronic tissue ulcers. They are multi-domain proteins and their activities are regulated by tissue inhibitors of metalloproteinases (TIMPs). This review introduces the members of the MMP family and discusses their domain structure and function, proenyme activation, the mechanism of inhibition by TIMPs and their significance in physiology and pathology.

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Animals Cardiovascular Diseases Cardiovascular System Extracellular Matrix Humans Matrix Metalloproteinase Inhibitors Matrix Metalloproteinases Structure-Activity Relationship Tissue Inhibitor of Metalloproteinases Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

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Hideaki Nagase, Robert Visse, Gillian Murphy. 2006-01-05. Structure and function of matrix metalloproteinases and TIMPs.. https://doi.org/10.1016/j.cardiores.2005.12.002

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