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PubMed · 16406772

Subversion of actin dynamics by EPEC and EHEC.

Emmanuelle Caron·Valerie F Crepin·Nandi Simpson·Stuart Knutton·Junkal Garmendia·Gad Frankel
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Abstract

During the course of infection, enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC, respectively) subvert the host cell signalling machinery and hijack the actin cytoskeleton to tighten their interaction with the gut epithelium, while avoiding phagocytosis by professional phagocytes. Much progress has been made recently in our understanding of how EPEC and EHEC regulate the pathways leading to local activation of two regulators of actin cytoskeleton dynamics, the Wiskott-Aldrich syndrome protein (N-WASP) and the Arp2/3 complex. A recent highlight is the unravelling of functions for effector proteins (particularly Tir, TccP, Map and EspG/EspG2) that are injected into the host cell by a type III secretion system.

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Actin-Related Protein 2-3 ComplexActinsAnimalsBacterial AdhesionCytoskeletonEscherichia coliEscherichia coli ProteinsHumansIntestinal MucosaReceptors, Cell SurfaceVirulence FactorsWiskott-Aldrich Syndrome Protein, NeuronalJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Emmanuelle Caron, Valerie F Crepin, Nandi Simpson, Stuart Knutton, Junkal Garmendia, Gad Frankel. 2006-01-06. Subversion of actin dynamics by EPEC and EHEC.. https://doi.org/10.1016/j.mib.2005.12.008

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