PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 1640775

Using the proportional hazards model to study heart valve replacement data.

B D Bunday·V A Kiri·K D Stoodley
View original source ↗Export metadata ↓

Abstract

The proportional hazards model is used to study the effect of various concomitant variables on the time to valve failure, mortality, or other complications, for patients who have had artificial heart valves inserted. The data are from a database, which is still being assembled as more information is acquired, at Killingbeck Hospital. A suite of computer programs, not specifically developed with this application in mind, has been used to carry out the exploratory data analysis, the estimation of parameters and the validation of the model. These three elements of the analysis are all illustrated. The present report is seen as a preliminary study to assess the usefulness of the proportional hazards model in this area. Follow-up work as more data are accumulated is intended.

Explore related subjects

BioprosthesisHeart Valve ProsthesisHumansMitral ValvePostoperative ComplicationsProportional Hazards ModelsProsthesis DesignProsthesis FailureSoftwareSurvival RateComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

B D Bunday, V A Kiri, K D Stoodley. Using the proportional hazards model to study heart valve replacement data.. https://doi.org/10.3109/14639239209012136

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Early outcomes of tricuspid valve replacement in young children.

BACKGROUND: Early outcomes after tricuspid valve replacement in young children are ill defined. The experience of the Pediatric Cardiac Care Consortium (45 centers, 1984 to 2002) was reviewed to evaluate the results of tricuspid valve replacement in children <6 years of age. METHODS AND RESULTS: Ninety-seven patients who underwent initial tricuspid valve replacement are included in the present analysis. The most frequent cardiac diagnoses were Ebstein's anomaly (40%), pulmonary atresia (11%), and tetralogy of Fallot (8%). Age at tricuspid valve replacement was 2.9+/-1.7 years (mean+/-SD). Mean patient weight was 12.7+/-6.1 kg. The major outcome was survival to discharge. Associations among age, diagnosis, valve type/size, and outcome were evaluated through the use of chi2 analysis and logistic regression model fitting approaches. Hospital mortality was 26% and was very high (64%) in patients <1 year of age. A large size-to-weight ratio was the strongest predictor of mortality based on multivariable analysis (P<0.001). Mortality was 54% for patients with a size-to-weight ratio >2.5. Other complications included heart block requiring a pacemaker (13%) and thrombosis (5%). Pacemaker implantation was associated with the use of a mechanical valve (23% versus 6% bioprosthetic valve; P=0.01) CONCLUSIONS: Tricuspid valve replacement in young children is associated with high mortality, especially in infants <1 year of age. Surgical options other than tricuspid valve replacement such as transplantation may need to be considered in infants.

Bioprosthesis↗