Collagen and elastin gene expression in aortic aneurysms.

C L Mesh; B T Baxter; W H Pearce; R L Chisholm; G S McGee; J S Yao

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PubMed · 1641765

Collagen and elastin gene expression in aortic aneurysms.

C L Mesh·B T Baxter·W H Pearce·R L Chisholm·G S McGee·J S Yao

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Abstract

BACKGROUND: The decreased elastin concentration found in abdominal aortic aneurysms (AAAs) may result from a differential synthetic response wherein elastin gene expression fails to increase in parallel with type I procollagen (COL I) gene expression. The purpose of this study is to determine tissue mRNA levels for elastin and COL I in AAAs compared with levels in normal, age-matched aorta and to determine the relationship between aging and COL I gene expression. METHODS: Total RNA exacted from normal infrarenal aortic tissue (n = 7) and AAA (n = 10) tissue was subjected to Northern analysis. Mean values for COL I, elastin, and alpha-tubulin mRNA levels were compared by use of the Student t test. Age and COL I mRNA levels were analyzed by regression analysis. RESULTS: COL I mRNA was increased significantly in AAAs (1.18 +/- 0.13) compared with normal aortas (0.14 +/- 0.05). A commensurate increase in elastin mRNA (AAAs, 0.11 +/- 0.02, vs normal aortas, 0.39 +/- 0.2) was absent. There was no correlation between age and COL gene expression. CONCLUSIONS: The decreased elastin concentration relative to collagen in AAAs may be explained, in part, by the changes in message level of elastin and collagen. The enhanced COL I gene expression in AAAs is unrelated to age.

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Aging Aorta, Abdominal Aortic Aneurysm Aortic Diseases Arterial Occlusive Diseases Autoradiography Blotting, Northern Elastin Gene Expression Humans Middle Aged Procollagen RNA, Messenger Comparative Study Journal Article Research Support, Non-U.S. Gov't

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C L Mesh, B T Baxter, W H Pearce, R L Chisholm, G S McGee, J S Yao. 1992. Collagen and elastin gene expression in aortic aneurysms.. https://pubmed.ncbi.nlm.nih.gov/1641765/

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