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Stat5a/b are essential for normal lymphoid development and differentiation.

Zhengju Yao·Yongzhi Cui·Wendy T Watford·Jay H Bream·Kunihiro Yamaoka·Bruce D Hissong·Denise Li·Scott K Durum·Qiong Jiang·Avinash Bhandoola·Lothar Hennighausen·John J O'Shea
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Abstract

Cytokines that use the common gamma chain gammac are critical for lymphoid development and function. Mutations of the IL-7 receptor, gammac, or its associated kinase, Jak3, are the major cause of human severe combined immunodeficiency. Although activated by IL-7, Stat5a/b (Stat, signal transducer and activator of transcription) have been thought to play limited roles in lymphoid development. However, we now show that mice completely deficient in Stat5a/b have severely impaired lymphoid development and differentiation. Absence of Stat5 also abrogates T cell receptor gamma rearrangement and survival of peripheral CD8(+) T cells. Thus, deficiency of Stat5 results in severe combined immunodeficiency, similar in many respects to deficiency of IL-7R, gammac, and Jak3.

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AnimalsB-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCell ProliferationCell TransplantationCytokinesFlow CytometryHyaluronan ReceptorsJanus Kinase 3LiverLymphocytesMiceMice, SCIDMutationProtein-Tyrosine KinasesRNAReceptors, Antigen, T-CellReceptors, Interleukin-7Reverse Transcriptase Polymerase Chain ReactionSTAT5 Transcription FactorSpleenT-LymphocytesTime FactorsJournal ArticleResearch Support, N.I.H., Intramural

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Zhengju Yao, Yongzhi Cui, Wendy T Watford, Jay H Bream, Kunihiro Yamaoka, Bruce D Hissong, Denise Li, Scott K Durum, Qiong Jiang, Avinash Bhandoola, Lothar Hennighausen, John J O'Shea. 2006-01-17. Stat5a/b are essential for normal lymphoid development and differentiation.. https://doi.org/10.1073/pnas.0507350103

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