AEOL-10150 (Aeolus).

Richard W Orrell

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PubMed · 16425674

AEOL-10150 (Aeolus).

Richard W Orrell

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Abstract

AEOL-10150, a small-molecule antioxidant analogous to the catalytic site of superoxide dismutase, is under development by Aeolus (formerly Incara) as a potential subcutaneous treatment for amyotrophic lateral sclerosis (ALS), stroke, spinal cord injury, lung inflammation and mucositis. The compound is currently undergoing a phase I clinical trial for ALS. In October 2005, the company had applied for Fast Track status, and planned to submit a special protocol assessment for a pivotal phase II/III trial.

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Animals Antioxidants Clinical Trials as Topic Humans Lung Diseases Metalloporphyrins Molecular Structure Neoplasms Nervous System Diseases Neuroprotective Agents Structure-Activity Relationship Treatment Outcome Journal Article Review

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Richard W Orrell. 2006. AEOL-10150 (Aeolus).. https://pubmed.ncbi.nlm.nih.gov/16425674/

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