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COX-2 expression in pseudomyxoma peritonei.

Zoran Gatalica·Brian Loggie
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Abstract

COX-2 expression was studied using an immunohistochemical method in 75 patients with pseudomyxoma peritonei (PMP). Twenty-five patients presented with disseminated peritoneal adenomucinosis (DPAM) and 50 with peritoneal mucinous carcinomatosis (PMCA). COX-2 was expressed in neoplastic mucinous epithelium of 30 cases (40%): 20 in PMCA (40%), 10 in DPAM (40%). Weak COX-2 expression was also noted in four of five patients with appendiceal mucinous neoplasms without peritoneal dissemination. In addition, COX-2 was detected in stromal, endothelial, inflammatory cells and reactive mesothelium. This preliminary information indicates a potential for the use of COX-2 inhibitors in patients with PMP.

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Adenocarcinoma, MucinousAdultAgedAppendiceal NeoplasmsCyclooxygenase 2Cystadenoma, MucinousEndothelial CellsEpitheliumFemaleHumansImmunoenzyme TechniquesMaleMembrane ProteinsMiddle AgedPeritoneal NeoplasmsPrognosisProspective StudiesPseudomyxoma PeritoneiErb-b2 Receptor Tyrosine KinasesStromal CellsJournal Article

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Zoran Gatalica, Brian Loggie. 2006-01-19. COX-2 expression in pseudomyxoma peritonei.. https://doi.org/10.1016/j.canlet.2005.12.013

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