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The molecular basis for calcium-dependent axon pathfinding.

Timothy M Gomez·James Q Zheng
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Abstract

Ca(2+) signals have profound and varied effects on growth cone motility and guidance. Modulation of Ca(2+) influx and release from stores by guidance cues shapes Ca(2+) signals, which determine the activation of downstream targets. Although the precise molecular mechanisms that underlie distinct Ca(2+)-mediated effects on growth cone behaviours remain unclear, recent studies have identified important players in both the regulation and targets of Ca(2+) signals in growth cones.

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AnimalsAxonsCalciumCalcium SignalingGrowth ConesHumansModels, NeurologicalNeuronsJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, Non-P.H.S.Review

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Timothy M Gomez, James Q Zheng. 2006. The molecular basis for calcium-dependent axon pathfinding.. https://doi.org/10.1038/nrn1844

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