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Immunologically mediated fatigue: a murine model.

C C Chao·M DeLaHunt·S Hu·K Close·P K Peterson
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Abstract

Chronic fatigue syndrome (CFS) is an idiopathic disorder in which the chief symptoms is profound fatigue. To explore the relationship between immune stimulation and fatigue, we developed a murine model for quantifying fatigue: reduction in voluntary running and delayed initiation of grooming after swimming. Inoculation of female BALB/c mice with Corynebacterium parvum antigen or the relatively avirulent Me49 strain of Toxoplasma gondii induced fatigue: baseline running reduced to less than 50 and 30% for 8 and 14 days, respectively, and delayed initiation of grooming after swimming in both immunologically stimulated groups. A threefold evaluation of serum transforming growth factor-beta levels, a cytokine increased in CFS patients, was found in fatigued C. parvum- and T. gondii-inoculated mice. This murine model appears promising for investigation of the pathogenesis of immunologically mediated fatigue.

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AnimalsAntigens, BacterialDisease Models, AnimalFatigue Syndrome, ChronicFemaleMiceMice, Inbred BALB CPhysical ExertionPropionibacterium acnesToxoplasmaTransforming Growth Factor betaUp-RegulationComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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C C Chao, M DeLaHunt, S Hu, K Close, P K Peterson. 1992. Immunologically mediated fatigue: a murine model.. https://doi.org/10.1016/0090-1229(92)90194-s

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