Bicyclic carbohydrate-derived scaffolds for combinatorial libraries.

Giovanni Cervi; Francesco Peri; Carlo Battistini; Cesare Gennari; Francesco Nicotra

doi:10.1016/j.bmc.2005.12.055

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Bicyclic carbohydrate-derived scaffolds for combinatorial libraries.

Giovanni Cervi·Francesco Peri·Carlo Battistini·Cesare Gennari·Francesco Nicotra

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Abstract

A bicyclic scaffold derived from the natural monosaccharide d-glucose, and possessing several diversity sites, was linked to various resins through the primary (C-6) hydroxyl and decorated on the solid phase: the hydroxyl group at C-4 was functionalized as ester, ether, and carbamate, the amino group in the second cycle (C-3' position) was functionalized as amide, sulfonamide, and ureido- and thioureido-derivatives. The compounds synthesized on the solid phase were tested for their antiproliferative activity on tumor cell lines.

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Antineoplastic Agents Bridged Bicyclo Compounds Carbohydrate Sequence Cell Line, Tumor Cell Proliferation Colonic Neoplasms Combinatorial Chemistry Techniques Drug Screening Assays, Antitumor Glucose Humans Male Molecular Sequence Data Molecular Structure Prostatic Neoplasms Pyrans Journal Article Research Support, Non-U.S. Gov't

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Giovanni Cervi, Francesco Peri, Carlo Battistini, Cesare Gennari, Francesco Nicotra. 2006-01-24. Bicyclic carbohydrate-derived scaffolds for combinatorial libraries.. https://doi.org/10.1016/j.bmc.2005.12.055

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