[Generalized erythema triggered by a rapid decrease of basophils in chronic myeloid leukemia treated with imatinib].

Motoko Sugito; Junichi Tsukada; Takehiro Higashi; Takanori Ohta; Ai Matsuura; Ayumu Kubota; Takamitsu Mizobe; Fumihiko Mouri; Hiroaki Morimoto; Yoshiya Tanaka

PubMed · 16440809

[Generalized erythema triggered by a rapid decrease of basophils in chronic myeloid leukemia treated with imatinib].

Motoko Sugito·Junichi Tsukada·Takehiro Higashi·Takanori Ohta·Ai Matsuura·Ayumu Kubota·Takamitsu Mizobe·Fumihiko Mouri·Hiroaki Morimoto·Yoshiya Tanaka

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Abstract

A 57-year-old woman with chronic myeloid leukemia showing severe basophilia (WBC 17.1 X 10(9)/L, basophils 23%) was treated with 400mg imatinib in June 2003. A high basophil count (WBC 10.6 X 10(9)/L, basophils 31%) was still observed after 1 week of therapy. After 9 days of therapy, she developed generalized pruritic skin erythema, chills and high fever. After terminating imatinib treatment, prednisolone therapy was initiated. The rash quickly disappeared. Four days after withdrawal of imatinib, leukocyte count was 13.0 X 10(9)/L with 3% of basophils, suggesting the possibility that rapid decrease in basophils following imatinib therapy may induce severe cutaneous reactions.

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Antineoplastic Agents Basophils Benzamides Erythema Female Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive Leukocytosis Leukopenia Middle Aged Piperazines Pyrimidines Severity of Illness Index Case Reports English Abstract Journal Article

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Motoko Sugito, Junichi Tsukada, Takehiro Higashi, Takanori Ohta, Ai Matsuura, Ayumu Kubota, Takamitsu Mizobe, Fumihiko Mouri, Hiroaki Morimoto, Yoshiya Tanaka. 2005. [Generalized erythema triggered by a rapid decrease of basophils in chronic myeloid leukemia treated with imatinib].. https://pubmed.ncbi.nlm.nih.gov/16440809/

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