Bcr interferes with beta-catenin-Tcf1 interaction.

Angelika Ress; Karin Moelling

doi:10.1016/j.febslet.2006.01.034

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Bcr interferes with beta-catenin-Tcf1 interaction.

Angelika Ress·Karin Moelling

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Abstract

The beta-catenin/Tcf complex is a downstream effector of the Wnt signalling pathway. It is a transcription complex, which activates gene expression and contributes to proliferation and tumor progression. Tcf1 in complex with beta-catenin is able to activate beta-catenin-dependent gene expression. We demonstrate that expressed Bcr is able to bind the transcription factor Tcf1 to disrupt the Tcf1/beta-catenin complex. Phosphorylation of Bcr by the tyrosine kinase pp60(src) can lead to dissociation of the transcriptionally inactive Bcr/Tcf1 complex. Thus two independent mechanisms may regulate Tcf/beta-catenin-mediated transcription via Bcr: binding to beta-catenin as we have previously shown and to Tcf1 as shown here.

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Animals Cell Line Hepatocyte Nuclear Factor 1-alpha Humans Multiprotein Complexes Phosphorylation Proto-Oncogene Proteins c-bcr Proto-Oncogene Proteins pp60(c-src)Transcription, Genetic Transfection beta Catenin Journal Article Research Support, Non-U.S. Gov't

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Angelika Ress, Karin Moelling. 2006-01-20. Bcr interferes with beta-catenin-Tcf1 interaction.. https://doi.org/10.1016/j.febslet.2006.01.034

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