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Patch fluorometry: shedding new light on ion channels.

Jie Zheng
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Abstract

Patch fluorometry has emerged as a new approach to the study of the structure-function relationship in membrane-embedded functional ion channels. Simultaneous fluorescent and electrical recordings are achieved from a small number of channels in a cell-free membrane patch, yielding high recording sensitivities. Further improvement of this approach should permit direct observation of the gating motion of a single-channel protein.

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AnimalsFluorescenceFluorometryHumansIon Channel GatingIon ChannelsMembrane PotentialsPatch-Clamp TechniquesJournal ArticleReview

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Jie Zheng. 2006. Patch fluorometry: shedding new light on ion channels.. https://doi.org/10.1152/physiol.00041.2005

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