PubMed · 164526
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W C Cooper. 1975. Editorial: Cadmium ... more epidemiologic work needed.. https://pubmed.ncbi.nlm.nih.gov/164526/
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Kidneys are particularly susceptible to the effect of toxic agents that can cause renal damage and even renal failure. The aim of this study was to present current knowledge of the influence of occupational toxic agents on renal functions. The authors describe the major nephrotoxic factors, such as heavy metals (including lead, cadmium, and mercury), organic solvents, pesticides and silica. They discuss changes in the kidney structure and molecular mechanisms of nephrotoxicity and carcinogenesis induced by occupational exposure to major toxic agents and also indicate possibilities of detecting the predicted nephrotoxicity symptoms so that clinical, overt renal insufficiency could be prevented.
Itai-itai (ouch-ouch) disease is a syndrome accompanied by bone mineral disorders that may be related to oral cadmium exposure. Itai-itai predominantly affects postmenopausal women with a history of multiple childbirth. In a previous study we have examined the genotype distributions of PvuII and XbaI restriction fragment length polymorphisms of the estrogen receptor alpha (ER alpha) gene in patients with itai-itai disease and compared them with those of controls. However, no significant differences were shown between the genotype distributions of the patients and controls. In the present study, we determined the TA repeat polymorphisms of the patients and controls. The distributions of the patients were: HH 25.0%, HL 50.0%, and LL 25.0%; where HH includes two alleles with a high number of TA repeats (TA> or =16), HL includes one high number allele and one low number allele (TA< or =15), and LL includes two alleles with a low number of TA repeats. These patients' distributions were not significantly different from those of the controls. Although our sample number was limited, we concluded that a polymorphism variant of the ER alpha gene is not a predisposing factor for itai-itai disease.
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