Specific changes in hippocampal spatial codes predict spatial working memory performance.

Corey B Puryear; Michael King; Sheri J Y Mizumori

doi:10.1016/j.bbr.2005.12.007

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Specific changes in hippocampal spatial codes predict spatial working memory performance.

Corey B Puryear·Michael King·Sheri J Y Mizumori

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Abstract

This study examined the relationship between hippocampal place fields and spatial working memory. Place cells were recorded while rats solved a spatial working memory task in light and dark testing conditions. Rats made significantly more errors when tested in darkness, and although place fields changed in multiple ways in darkness, only changes in place field specificity predicted the degree of impaired spatial memory. This finding suggests that more spatially distinct place fields may contribute to hippocampal-dependent mnemonic functions.

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Animals Evoked Potentials Hippocampus Male Maze Learning Memory, Short-Term Rats Rats, Long-Evans Space Perception Comparative Study Journal Article Research Support, N.I.H., Extramural

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Corey B Puryear, Michael King, Sheri J Y Mizumori. 2006-02-02. Specific changes in hippocampal spatial codes predict spatial working memory performance.. https://doi.org/10.1016/j.bbr.2005.12.007

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