Control by cholinergic mechanisms.

Kurt Racké; Uwe R Juergens; Sonja Matthiesen

doi:10.1016/j.ejphar.2005.12.050

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Control by cholinergic mechanisms.

Kurt Racké·Uwe R Juergens·Sonja Matthiesen

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Abstract

In the respiratory tract acetylcholine is neurotransmitter in ganglia and postganglionic parasympathetic nerves, but in addition is paracrine mediator released from various non-neuronal cells. Almost every cell type present in the respiratory tract expresses nicotinic and muscarinic receptors and therefore appears to be a target for acetylcholine. The present review describes the mechanisms of synthesis and release of acetylcholine from neuronal and non-neuronal cells and the differential control mechanisms. The different cholinoceptors, multiple nicotinic and muscarinic receptors and their signalling are outlined and their involvement in the modulation of the function of various target cells, smooth muscles, nerves, surface epithelial, secretory cells, fibroblasts and inflammatory cells is discussed in detail.

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Acetylcholine Animals Bronchoconstriction Fibroblasts Ganglia, Parasympathetic Humans Muscle, Smooth Paracrine Communication Parasympathetic Fibers, Postganglionic Receptors, Muscarinic Receptors, Nicotinic Respiratory Mucosa Respiratory System Signal Transduction Synaptic Transmission Journal Article Review

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Kurt Racké, Uwe R Juergens, Sonja Matthiesen. 2006-02-03. Control by cholinergic mechanisms.. https://doi.org/10.1016/j.ejphar.2005.12.050

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