Receptor editing for better or for worse.

Roberta Pelanda; Raul M Torres

doi:10.1016/j.coi.2006.01.005

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PubMed · 16460922

Receptor editing for better or for worse.

Roberta Pelanda·Raul M Torres

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Abstract

Receptor editing has emerged from its original identification as a minor secondary mechanism of B cell tolerance to be considered as a dominant mechanism by which autoreactive immature B cells are rendered tolerant. Clonal deletion, previously regarded as the major mechanism of central B cell tolerance, has been shown by recent studies to operate secondarily and only when receptor editing is unable to provide a non-autoreactive specificity. Receptor editing has also been shown to operate during the development of wild-type B lymphocytes, and ongoing investigations demonstrate the influence of particular signaling molecules in the induction and/or inhibition of receptor editing. Together, these studies begin to map the signaling pathways that regulate receptor editing in autoreactive and non-autoreactive immature B cells.

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Animals B-Lymphocytes Humans Models, Immunological Receptors, Antigen, B-Cell Signal Transduction Journal Article Research Support, N.I.H., Extramural Review

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Roberta Pelanda, Raul M Torres. 2006-02-03. Receptor editing for better or for worse.. https://doi.org/10.1016/j.coi.2006.01.005

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