AID in somatic hypermutation and class switch recombination.

Simonne Longerich; Uttiya Basu; Frederick Alt; Ursula Storb

doi:10.1016/j.coi.2006.01.008

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AID in somatic hypermutation and class switch recombination.

Simonne Longerich·Uttiya Basu·Frederick Alt·Ursula Storb

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Abstract

Somatic hypermutation and class-switch-recombination are initiated by the deamination of deoxycytosine in DNA by activation-induced-deaminase, AID. Recently, there has been much research into how AID targets double-stranded DNA in sub-regions of Ig genes, the involvement of co-factors and posttranslational modifications in this process, the co-option of DNA 'repair' mechanisms and AID evolution.

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Animals Cytidine Deaminase DNA Humans Immunoglobulin Class Switching Immunoglobulin Switch Region Models, Immunological Recombination, Genetic AICDA (Activation-Induced Cytidine Deaminase)Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

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Simonne Longerich, Uttiya Basu, Frederick Alt, Ursula Storb. 2006-02-07. AID in somatic hypermutation and class switch recombination.. https://doi.org/10.1016/j.coi.2006.01.008

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