Human interleukin 4.

J Banchereau; T Defrance; J P Galizzi; P Miossec; F Rousset

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PubMed · 1647238

Human interleukin 4.

J Banchereau·T Defrance·J P Galizzi·P Miossec·F Rousset

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Abstract

Human IL-4 is a mature 129 AA glycoprotein, mostly secreted by activated T cells. It is a pleiotropic cytokine which acts on T and B lymphocytes, monocytes, polymorphonuclear cells, fibroblasts and endothelial cells. In addition it acts at various stages of cell differentiation and its effects are also dependent on the cytokine environment. In particular, IL-4 blocks some of the effects of IL-2 whereas interferon gamma blocks some of the effects of IL-4. In vitro and in vivo experiments in mouse and in vitro experiments in man have shown that IL-4 plays a crucial role in the induction of IgE production, whereas interferons counteract this effect. Human IL-4 binds to a high affinity receptor which is composed at least of one 130-kDa glycoprotein of 800 AA, a member of the newly described hematopoietin receptor superfamily. IL-4 may prove useful as an antitumoral and antiinflammatory agent.

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Animals B-Lymphocytes Humans Interleukin-4 Mice Receptors, Cell Surface T-Lymphocytes Journal Article Review

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J Banchereau, T Defrance, J P Galizzi, P Miossec, F Rousset. 1991. Human interleukin 4.. https://pubmed.ncbi.nlm.nih.gov/1647238/

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