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T-sing progenitors to commit.

Floor Weerkamp·Karin Pike-Overzet·Frank J T Staal
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Abstract

T-cell development in the thymus is a complex and highly regulated process. During the process of differentiation from multipotent progenitor cells to mature T cells, proliferation, restriction of lineage potential, TCR gene rearrangements and selection events occur, all accompanied by changes in gene expression. A comprehensive understanding of thymocyte differentiation remains to be established. Two related, key issues have received much attention recently: the nature of the thymus seeding cell and the regulation of T-cell lineage commitment. Here we review the perspectives of different researchers working both on murine and human T-cell development and argue that a true T-cell commitment factor might not be required because of the unique properties of the thymus.

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AnimalsB-LymphocytesBone Marrow CellsCell LineageGene Rearrangement, T-LymphocyteHumansLymphopoiesisSignal TransductionStem CellsT-LymphocytesThymus GlandJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Floor Weerkamp, Karin Pike-Overzet, Frank J T Staal. 2006-02-10. T-sing progenitors to commit.. https://doi.org/10.1016/j.it.2006.01.006

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