Peak compression in reversed-phase gradient elution.

Uwe D Neue; Daniel H Marchand; Lloyd R Snyder

doi:10.1016/j.chroma.2006.01.104

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Peak compression in reversed-phase gradient elution.

Uwe D Neue·Daniel H Marchand·Lloyd R Snyder

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Abstract

Previous reports suggest that peak widths in linear gradient elution are consistently larger than predicted by theory; however, if gradient compression is ignored, experiment and theory are in reasonable agreement. This suggests that gradient compression might represent an incorrect or poorly understood concept. In the present study, an experimental program was carried out to better understand the role of gradient compression and the reason for past differences between experiment and theory. It is concluded that the concept of gradient compression is correct.

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Uwe D Neue, Daniel H Marchand, Lloyd R Snyder. 2006-02-13. Peak compression in reversed-phase gradient elution.. https://doi.org/10.1016/j.chroma.2006.01.104

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