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PubMed · 16474854

Rituximab.

Tanya Doan·Elena Massarotti
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Abstract

Rituximab is a chimeric monoclonal antibody that targets the CD20 molecule on the B-cell surface. It is the first antibody of its kind to be licensed for the treatment of non-Hodgkin's lymphoma. Rituximab was found to be effective, well-tolerated and has a good safety profile, though its precise cellular effects are still not well understood. Rituximab has been shown to be of therapeutic benefit in various autoimmune diseases in which B lymphocytes play a role. This article summarizes the current literature regarding the use of rituximab in lymphoma, rheumatoid arthritis, systemic lupus erythematosus and other selected autoimmune diseases.

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Antibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedAutoimmune DiseasesClinical Trials as TopicHumansLymphoma, B-CellRituximabJournal ArticleReview

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Tanya Doan, Elena Massarotti. 2005. Rituximab.. https://doi.org/10.1358/dot.2005.41.12.953591

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