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B-cell tolerance.

Helen Ferry·Janson C H Leung·Graham Lewis·Anastasia Nijnik·Karlee Silver·Teresa Lambe·Richard J Cornall
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Abstract

Autoreactive B cells are actively tolerized to more abundant self-antigens by a series of checkpoints involving receptor editing, deletion, anergy and competition for growth factors. In contrast, B cells reactive against rare, sequestered or tissue specific self-antigens remain functionally naïve. During an immune response, the autoimmune danger from these cells is countered by a variety of mechanisms comprising control of self-antigen presentation, limitation of immunogenic and tolerogenic costimuli including T cell help, homeostatic control of growth and strict regulation of germinal centre reactions. In this overview we consider how knowledge of these checkpoints may be used to gain a better understanding of transplant tolerance and the generation of alloantibodies.

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AutoantigensAutoimmunityB-LymphocytesClonal AnergyHumansT-Lymphocytes, Helper-InducerTransplantation ImmunologyTransplantation ToleranceJournal ArticleReview

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Helen Ferry, Janson C H Leung, Graham Lewis, Anastasia Nijnik, Karlee Silver, Teresa Lambe, Richard J Cornall. 2006-02-15. B-cell tolerance.. https://doi.org/10.1097/01.tp.0000203830.79357.39

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