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More TORC for the gluconeogenic engine.

Alan Cheng·Alan R Saltiel
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Abstract

Hepatic gluconeogenesis plays a key role in the maintenance of glucose homeostasis. The hormone glucagon stimulates this process, whereas insulin and adiponectin are inhibitory. In a recent report, Koo et al identify the transcriptional regulator TORC2 (Transducer of Regulated CREB activity 2) as a pivotal component of the gluconeogenic program.1 Both insulin and AMPK increase the phosphorylation of TORC2, while glucagon suppresses it. This in turn regulates the nuclear/cytoplasmic shuttling of TORC2 and its ability to transactivate gluconeogenic genes. Thus, TORC2 might serve as a gluconeogenic "molecular switch" that senses hormones and cellular energy status.

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AMP-Activated Protein KinasesCyclic AMP Response Element-Binding ProteinGene Expression RegulationGlucagonGluconeogenesisHumansInsulinLiverMultienzyme ComplexesPhosphoproteinsProtein Serine-Threonine KinasesTranscription FactorsJournal Article

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Alan Cheng, Alan R Saltiel. 2006. More TORC for the gluconeogenic engine.. https://doi.org/10.1002/bies.20375

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