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A visual approach to proteomics.

Stephan Nickell·Christine Kofler·Andrew P Leis·Wolfgang Baumeister
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Abstract

Cryo-electron tomography is an emerging imaging technique that has unique potential for molecular cell biology. At the present resolution of 4-5 nm, large supramolecular structures can be studied in unperturbed cellular environments and, in the future, it will become possible to map molecular landscapes inside cells in a more comprehensive manner. 'Visual proteomics' aims to complement and extend mass-spectrometry-based inventories, and to provide a quantitative description of the macromolecular interactions that underlie cellular functions.

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Cryoelectron MicroscopyMicroscopy, ElectronProteinsProteomeRhodophytaJournal ArticleReview

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Stephan Nickell, Christine Kofler, Andrew P Leis, Wolfgang Baumeister. 2006. A visual approach to proteomics.. https://doi.org/10.1038/nrm1861

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