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FbsA-driven fibrinogen polymerization: a bacterial "deceiving strategy".

Matteo Pierno·Laura Maravigna·Roberto Piazza·Livia Visai·Pietro Speziale
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Abstract

We show that FbsA, a cell wall protein of the bacterium Streptococcus agalactiae, promotes large-scale aggregation of human plasma fibrinogen, leading to the formation of a semiflexible polymerlike network. This extensive aggregation process takes place not only in solution, but also on FbsA-functionalized colloidal particles, and leads to the formation of a thick layer on the bacterial cell wall itself, which becomes an efficient mask against phagocytosis.

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Bacterial ProteinsBiopolymersCarrier ProteinsColloidsFibrinogenStreptococcus agalactiaeJournal ArticleResearch Support, Non-U.S. Gov't

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Matteo Pierno, Laura Maravigna, Roberto Piazza, Livia Visai, Pietro Speziale. 2006-01-20. FbsA-driven fibrinogen polymerization: a bacterial "deceiving strategy".. https://doi.org/10.1103/physrevlett.96.028108

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