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CDK activation by non-cyclin proteins.

Angel R Nebreda
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Abstract

Progression through the cell cycle is regulated by cyclin-dependent kinases (CDKs), which associate with activating partners, named cyclins, to phosphorylate substrates efficiently. Cyclins are periodically synthesized and degraded during the cell cycle, playing a key role in the precise activation and inactivation of CDKs. However, CDKs can also be activated by other proteins, which lack sequence similarity to cyclins. These include the RINGO/Speedy proteins, which were originally identified as regulators of the meiotic cell cycle in Xenopus oocytes. Recently, five different mammalian RINGO/Speedy family members have been reported, all of which can bind to and directly activate Cdk1 and Cdk2.

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AnimalsCDC2 Protein KinaseCell CycleCell Cycle ProteinsCyclin-Dependent Kinase 2Cyclin-Dependent KinasesEnzyme ActivationHumansModels, BiologicalNerve Tissue ProteinsPhylogenyXenopus ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Angel R Nebreda. 2006-02-17. CDK activation by non-cyclin proteins.. https://doi.org/10.1016/j.ceb.2006.01.001

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