Minimotif Miner: a tool for investigating protein function.

Sudha Balla; Vishal Thapar; Snigdha Verma; Thaibinh Luong; Tanaz Faghri; Chun-Hsi Huang; Sanguthevar Rajasekaran; Jacob J del Campo; Jessica H Shinn; William A Mohler; Mark W Maciejewski; Michael R Gryk; Bryan Piccirillo; Stanley R Schiller; Martin R Schiller

doi:10.1038/nmeth856

PubMed · 16489333

Minimotif Miner: a tool for investigating protein function.

Sudha Balla·Vishal Thapar·Snigdha Verma·Thaibinh Luong·Tanaz Faghri·Chun-Hsi Huang·Sanguthevar Rajasekaran·Jacob J del Campo·Jessica H Shinn·William A Mohler·Mark W Maciejewski·Michael R Gryk·Bryan Piccirillo·Stanley R Schiller·Martin R Schiller

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Abstract

In addition to large domains, many short motifs mediate functional post-translational modification of proteins as well as protein-protein interactions and protein trafficking functions. We have constructed a motif database comprising 312 unique motifs and a web-based tool for identifying motifs in proteins. Functional motifs predicted by MnM can be ranked by several approaches, and we validated these scores by analyzing thousands of confirmed examples and by confirming prediction of previously unidentified 14-3-3 motifs in EFF-1.

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14-3-3 Proteins Amino Acid Motifs Amino Acid Sequence Animals Caenorhabditis elegans Proteins Databases as Topic Internet Membrane Glycoproteins Molecular Sequence Data Proteins Sequence Alignment Sequence Analysis, Protein Software Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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Sudha Balla, Vishal Thapar, Snigdha Verma, Thaibinh Luong, Tanaz Faghri, Chun-Hsi Huang, Sanguthevar Rajasekaran, Jacob J del Campo, Jessica H Shinn, William A Mohler, Mark W Maciejewski, Michael R Gryk, Bryan Piccirillo, Stanley R Schiller, Martin R Schiller. 2006. Minimotif Miner: a tool for investigating protein function.. https://doi.org/10.1038/nmeth856

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