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Early ischemic edema on cerebral computed tomography: its relation to diffusion changes and hypoperfusion within 6 h after human ischemic stroke. A comparison of CT, MRI and PET.

Jan Sobesky·Rüdiger von Kummer·Monika Frackowiak·Olivier Zaro Weber·Fritz G Lehnhardt·Christian Dohmen·Michael Neveling·Walter Möller-Hartmann·Andreas H Jacobs·Wolf-Dieter Heiss
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Abstract

BACKGROUND: Brain tissue hypoattenuation on early computed tomography is frequently included in decision making in acute stroke management. However, its pathophysiological counterpart needs further evaluation. METHODS: By comparative imaging with diffusion-weighted imaging and 15O-water positron emission tomography we aimed to interpret early (<6 h) hypoattenuation. RESULTS: In 11 patients, the hypoattenuation corresponded to a decreased proton diffusion (median 115.9% relative DWI value) measured by magnetic resonance imaging and to a severe hypoperfusion (below 12 ml/100 g/ min) assessed by positron emission tomography. The volume of parenchymal hypoattenuation correlated to the tissue with disturbed diffusion (Spearman's rho=0.73), but largely underestimated the hypoperfusion below 20 ml/100 g/min. CONCLUSIONS: Early hypoattenuation reflects the coupling of the severity of ischemia and resulting diffusion changes. It allows an estimate of the infarct core but underestimates the penumbral hypoperfusion.

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AdultAgedAged, 80 and overBrain EdemaCerebrovascular CirculationDiffusion Magnetic Resonance ImagingFollow-Up StudiesHumansInfarction, Middle Cerebral ArteryMiddle AgedPositron-Emission TomographyTime FactorsTomography, X-Ray ComputedComparative StudyJournal Article

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Jan Sobesky, Rüdiger von Kummer, Monika Frackowiak, Olivier Zaro Weber, Fritz G Lehnhardt, Christian Dohmen, Michael Neveling, Walter Möller-Hartmann, Andreas H Jacobs, Wolf-Dieter Heiss. 2006-02-14. Early ischemic edema on cerebral computed tomography: its relation to diffusion changes and hypoperfusion within 6 h after human ischemic stroke. A comparison of CT, MRI and PET.. https://doi.org/10.1159/000091539

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