Structure optimization of microvascular scaffolds.

Gou-Jen Wang; Yi-Feng Hsu

doi:10.1007/s10544-006-6382-x

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PubMed · 16491331

Structure optimization of microvascular scaffolds.

Gou-Jen Wang·Yi-Feng Hsu

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Abstract

In this research, a systematic method for the design of a usable microvascular network based on the commercial software FEMLAB is proposed. The design principle comes out to be that the usable network should made up of multi branches with no more than two vertical nodes in individual branch. A special mask was designed to process the microvessel network for experimental verification of velocity uniformity. Accordingly, a simple lithograph approach, in which the PMMA polymer was selected as the substrate, the negative photoresist JSR was employed to form the microchannel structure, was implemented to fabricate the network. Experimental results verified the uniformity of the velocity profile in the microvessel network.

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Animals Biocompatible Materials Cell Culture Techniques Cells, Cultured Computer-Aided Design Endothelial Cells Equipment Design Equipment Failure Analysis Humans Materials Testing Microcirculation Photography Polymethyl Methacrylate Surface Properties Tissue Engineering Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

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Gou-Jen Wang, Yi-Feng Hsu. 2006. Structure optimization of microvascular scaffolds.. https://doi.org/10.1007/s10544-006-6382-x

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