PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 16492158

Vicinal diamino functionalities as privileged structural elements in biologically active compounds and exploitation of their synthetic chemistry.

S R S Saibabu Kotti·Cody Timmons·Guigen Li
View original source ↗Export metadata ↓

Abstract

The chemistry, synthetic routes and medicinal properties of vicinal diamines and imidazolines are discussed. Synthetic routes towards chemically and pharmaceutically important molecules containing vicinal diamine functionality are discussed in detail. This mini review article covers the new developments of diamine chemistry between 2000 and 2005.

Explore related subjects

DiaminesImidazolinesPharmacologyJournal ArticleResearch Support, N.I.H., ExtramuralReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

S R S Saibabu Kotti, Cody Timmons, Guigen Li. 2006. Vicinal diamino functionalities as privileged structural elements in biologically active compounds and exploitation of their synthetic chemistry.. https://doi.org/10.1111/j.1747-0285.2006.00347.x

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

Emission efficiency of diamine derivatives of tris[4,4,4-trifluoro-1-(2-thienyl)-1,3-butanediono]europium.

Diamine derivatives of tris[4,4,4-trifluoro-1-(2-thienyl)-1,3-butanediono]europium were synthesized and characterized by NMR, IR and UV-vis spectroscopy. The emission efficiency and decay times of the produced Eu(III) coordination complexes in acetone solutions were measured upon ligand excitation. The effect of the amine ligands was studied and the relation between the emission and the structure of the synthesized compounds was discussed.

Diamines↗
PubMed2006

FTIR spectroscopic characterization of polyurethane-urea model hard segments (PUUMHS) based on three diamine chain extenders.

Six polyurethane-urea model hard segments (PUUMHS) were prepared by a solution method based, respectively, on two isocyanates: 4,4'-methylene-diphenyl-diisocyanate (MDI), 4,4'-methylene-dicyclohexyl diisocyanate (HMDI) and three amine chain extenders: ethylene diamine (EDA), methylene-bis-ortho-chloroaniline (MOCA), 2,4-diamino-3,5-dimethylsuphylchlorobenzene (DDSCB). FTIR was used to study their spectroscopic characterization. The main FTIR bands of the six samples were assigned and compared. It was found that most of N-H and C=O are H-bonded in these PUUMHS. However, the N-H in three MDI based PUUMHS is all in the stronger H-bond state than that in their corresponding HMDI based while the C=O in three HMDI based PUUMHS is all in the stronger H-bond state than that in their corresponding MDI based, respectively. In addition, the order of the H-bond strength in HMDI based PUUMHS is MOCA, DDSCB and EDA whether according to nuN-H or nuC=O band wavenumbers, which is, however, different from that in MDI based PUUMHS. Moreover, the HMDI based PUUMHS shows obvious double amide III bands while the MDI based has only prominent one. The results are discussed according mainly to the different characteristics of the three chain extenders as well as the structure difference between MDI and HMDI.

Diamines↗