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PubMed · 16492810

A +TIP for a smooth trip.

Xin Xiang
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Abstract

Is there a cellular mechanism for preventing a depolymerizing microtubule track from "slipping out from under" its cargo? A recent study in budding yeast indicates that when a chromosome is transported to the minus end of a spindle microtubule, its kinetochore-bound microtubule plus end-tracking protein (+TIP) Stu2 may move to the plus end to promote rescue; i.e., to switch the depolymerizing end to a polymerizing end. The possibility that other +TIPs may play a similar role in sustaining a microtubule track during vesicular transport deserves investigation.

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AnimalsBiological Transport, ActiveMicrotubule ProteinsMicrotubule-Associated ProteinsMolecular Motor ProteinsNeoplasm ProteinsSaccharomyces cerevisiae ProteinsJournal ArticleResearch Support, N.I.H., ExtramuralReview

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Xin Xiang. 2006-02-21. A +TIP for a smooth trip.. https://doi.org/10.1083/jcb.200511081

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