Making digit patterns in the vertebrate limb.

Cheryll Tickle

doi:10.1038/nrm1830

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Making digit patterns in the vertebrate limb.

Cheryll Tickle

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Abstract

The vertebrate limb has been a premier model for studying pattern formation - a striking digit pattern is formed in human hands, with a thumb forming at one edge and a little finger at the other. Classic embryological studies in different model organisms combined with new sophisticated techniques that integrate gene-expression patterns and cell behaviour have begun to shed light on the mechanisms that control digit patterning, and stimulate re-evaluation of the current models.

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Animals Body Patterning Embryonic Development Extremities Humans Journal Article Research Support, Non-U.S. Gov't Review

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Cheryll Tickle. 2006. Making digit patterns in the vertebrate limb.. https://doi.org/10.1038/nrm1830

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