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Detecting hepatitis B surface antigen mutants.

Paul F Coleman
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Abstract

Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels. HBsAg mutants present as false-negative results in some immunoassays. An understanding of immunoassay reactivity with HBsAg mutants is key to establishing an appropriate testing algorithm for hepatitis B virus detection programs.

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ChildHepatitis BHepatitis B Surface AntigensHepatitis B virusHumansImmunoassayModels, MolecularMutationReagent Kits, DiagnosticJournal Article

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Paul F Coleman. 2006. Detecting hepatitis B surface antigen mutants.. https://doi.org/10.3201/eid1203.050038

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