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Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus.

Longzhu Cui·Eiji Tominaga·Hui-Min Neoh·Keiichi Hiramatsu
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Abstract

We present here findings of a strong positive correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus (VISA). This correlation is related to cell wall thickening, suggesting that, similar to the case with vancomycin resistance in VISA, the physical barrier of a thickened cell wall may contribute to daptomycin resistance in S. aureus.

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Anti-Bacterial AgentsCell WallDaptomycinLinear ModelsMicrobial Sensitivity TestsStaphylococcal InfectionsStaphylococcus aureusVancomycinVancomycin ResistanceJournal ArticleResearch Support, Non-U.S. Gov't

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Longzhu Cui, Eiji Tominaga, Hui-Min Neoh, Keiichi Hiramatsu. 2006. Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus.. https://doi.org/10.1128/aac.50.3.1079-1082.2006

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