Bradykinin and peripheral sensitization.

Haibin Wang; Corina Ehnert; Gary J Brenner; Clifford J Woolf

doi:10.1515/bc.2006.003

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Bradykinin and peripheral sensitization.

Haibin Wang·Corina Ehnert·Gary J Brenner·Clifford J Woolf

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Abstract

Pain hypersensitivity after tissue injury and inflammation is contributed to by a reduction in the threshold and an increase in the responsiveness of the peripheral terminals of high-threshold nociceptor neurons, the phenomenon of peripheral sensitization. Bradykinin, acting via G-protein-coupled receptors expressed by the sensory neurons, links to multiple intracellular signaling pathways that in turn interact with voltage-gated and ligand-gated ion channels, changing their properties in such a way as to enhance the response to peripheral stimuli.

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Animals Bradykinin Humans Hyperalgesia Nociceptors Pain Peripheral Nervous System Signal Transduction Voltage-Dependent Anion Channels Journal Article Review

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Haibin Wang, Corina Ehnert, Gary J Brenner, Clifford J Woolf. 2006. Bradykinin and peripheral sensitization.. https://doi.org/10.1515/bc.2006.003

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