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PubMed · 16497588

Pathogen recognition and innate immunity.

Shizuo Akira·Satoshi Uematsu·Osamu Takeuchi
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Abstract

Microorganisms that invade a vertebrate host are initially recognized by the innate immune system through germline-encoded pattern-recognition receptors (PRRs). Several classes of PRRs, including Toll-like receptors and cytoplasmic receptors, recognize distinct microbial components and directly activate immune cells. Exposure of immune cells to the ligands of these receptors activates intracellular signaling cascades that rapidly induce the expression of a variety of overlapping and unique genes involved in the inflammatory and immune responses. New insights into innate immunity are changing the way we think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.

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Adaptation, PhysiologicalAnimalsCell WallCytokinesCytoplasmDrosophilaGram-Negative BacteriaGram-Positive BacteriaHumansImmunity, InnateMembrane GlycoproteinsModels, BiologicalRNA HelicasesRNA, Double-StrandedReceptors, Cell SurfaceSignal TransductionToll-Like ReceptorsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi. 2006-02-24. Pathogen recognition and innate immunity.. https://doi.org/10.1016/j.cell.2006.02.015

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