Chromatin assembly: a basic recipe with various flavours.

Sophie E Polo; Geneviève Almouzni

doi:10.1016/j.gde.2006.02.011

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Chromatin assembly: a basic recipe with various flavours.

Sophie E Polo·Geneviève Almouzni

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Abstract

Packaging of eukaryotic genomes into chromatin is a hierarchical mechanism, starting with histone deposition onto DNA to produce nucleosome arrays, which then further fold and ultimately form functional domains. Recent studies provide interesting insight into how nucleosome assembly is coordinated with histone and DNA metabolism and underline the combined contribution of histone chaperones and chromatin remodelers. How these factors operate at a molecular level is a matter of current investigation. New data highlight the importance of histone dimers as deposition entities for de novo nucleosome assembly and identify dedicated machineries involved in histone variant deposition.

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Animals Chromatin Chromatin Assembly and Disassembly Chromosomal Proteins, Non-Histone DNA Histones Humans Models, Biological Molecular Chaperones Nucleosomes Journal Article Research Support, Non-U.S. Gov't Review

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Sophie E Polo, Geneviève Almouzni. 2006-02-28. Chromatin assembly: a basic recipe with various flavours.. https://doi.org/10.1016/j.gde.2006.02.011

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