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PubMed · 16505594

Probucol and atorvastatin decrease urinary 8-hydroxy-2'-deoxyguanosine in patients with diabetes and hypercholesterolemia.

Kei Endo·Yoh Miyashita·Hidehisa Sasaki·Mariko Ebisuno·Masahiro Ohira·Atsuhito Saiki·Nobukiyo Koide·Tomokazu Oyama·Murano Takeyoshi·Koji Shirai
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Abstract

To clarify whether probucol and statins suppress oxidative stress in diabetic patients, we studied the effects of probucol and the statin atorvastatin on urinary 8-hydroxy-2'deoxyguanosine (8-OHdG) levels in diabetics with hypercholesterolemia. A randomized, open study was performed on a total of 36 patients with type 2 diabetes and hypercholesterolemia. The patients were randomly assigned to a probucol group (500 mg/day, n = 18) or an atorvastatin group (10 mg/day, n = 18). During three months, total- and LDL-cholesterol decreased significantly in both groups. LDL-cholesterol was significantly lower in the atorvastatin group than probucol group. HDL-C decreased significantly in the probucol group and did not change in the atorvastatin group. 8-OHdG decreased significantly in both groups after 3 months; 12.4 +/- 7.5 to 8.1 +/- 4.2 ng/mg/Cr in the atorvastatin group (p < 0.05) and 12.3 +/- 8.8 to 6.8 +/- 2.6 ng/mg/Cr in the probucol group (p < 0.05), and these changes did not differ significantly between the two groups. But, in patients with high 8-OHdG levels (more than 10 ng/mg/Cr) before administration, urinary 8-OHdG decreased significantly from 19.5 +/- 4.9 to 9.2 +/- 3.4 ng/mg Cr (p < 0.01) in the atorvastatin group, and from 19.7 +/- 8.2 to 6.67 +/- 2.2 ng/mg Cr (p < 0.01) in the probucol group. Urinary 8-OHdG was significantly lower in the probucol group than in the atorvastatin group after the second and third months of administration (p < 0.05). These results suggest that while probucol and atorvastatin both reduce systemic oxidative stress, probucol might be the more useful in patients with strong oxidative stress.

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8-Hydroxy-2'-DeoxyguanosineAdultAnticholesteremic AgentsAntioxidantsAtorvastatinBiomarkersDeoxyguanosineDiabetes Mellitus, Type 2FemaleHeptanoic AcidsHumansHypercholesterolemiaMaleMiddle AgedOxidative StressProbucolPyrrolesTreatment OutcomeJournal ArticleRandomized Controlled Trial

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Kei Endo, Yoh Miyashita, Hidehisa Sasaki, Mariko Ebisuno, Masahiro Ohira, Atsuhito Saiki, Nobukiyo Koide, Tomokazu Oyama, Murano Takeyoshi, Koji Shirai. 2006. Probucol and atorvastatin decrease urinary 8-hydroxy-2'-deoxyguanosine in patients with diabetes and hypercholesterolemia.. https://doi.org/10.5551/jat.13.68

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