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Evidence for a functional second thymus in mice.

Grzegorz Terszowski·Susanna M Müller·Conrad C Bleul·Carmen Blum·Reinhold Schirmbeck·Jörg Reimann·Louis Du Pasquier·Takashi Amagai·Thomas Boehm·Hans-Reimer Rodewald
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Abstract

The thymus organ supports the development of T cells and is located in the thorax. Here, we report the existence of a second thymus in the mouse neck, which develops after birth and grows to the size of a small lymph node. The cervical thymus had a typical medulla-cortex structure, was found to support T cell development, and could correct T cell deficiency in athymic nude mice upon transplantation. The identification of a regular second thymus in the mouse may provide evolutionary links to thymus organogenesis in other vertebrates and suggests a need to reconsider the effect of thoracic thymectomy on de novo T cell production.

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AnimalsAnimals, NewbornChoristomaForkhead Transcription FactorsHematopoietic Stem CellsHepatitis B AntibodiesHepatitis B Surface AntigensHistocompatibility Antigens Class IIImmunocompetenceLymphopoiesisMiceMice, Inbred BALB CMice, Inbred C57BLMice, NudeNeckReceptors, Antigen, T-CellSelf ToleranceT-LymphocytesThymectomyThymus GlandJournal ArticleResearch Support, Non-U.S. Gov't

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Grzegorz Terszowski, Susanna M Müller, Conrad C Bleul, Carmen Blum, Reinhold Schirmbeck, Jörg Reimann, Louis Du Pasquier, Takashi Amagai, Thomas Boehm, Hans-Reimer Rodewald. 2006-03-02. Evidence for a functional second thymus in mice.. https://doi.org/10.1126/science.1123497

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