Target selectivity in mRNA silencing.

N Aronin

doi:10.1038/sj.gt.3302726

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Target selectivity in mRNA silencing.

N Aronin

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Abstract

Despite the excitement and promise of RNA interference in treating neurodegenerative disease, disease gene mRNA might resist mRNA silencing. Conventional siRNA design does not uniformly distinguish a mutant from a wild-type allele. CAG expansions in trinucleotide repeat diseases are unselective targets for small siRNAs. This review will consider recent discoveries in mechanisms of RNA interference and siRNA modifications that improve siRNA selectivity, delivery and performance.

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Animals Gene Targeting Genetic Engineering Genetic Therapy Humans Huntington Disease Mutation RNA Interference RNA, Small Interfering RNA-Induced Silencing Complex Journal Article Review

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N Aronin. 2006. Target selectivity in mRNA silencing.. https://doi.org/10.1038/sj.gt.3302726

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