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PubMed · 16522048

A fluorescent nanosensor for apoptotic cells.

Luisa Quinti·Ralph Weissleder·Ching-Hsuan Tung
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Abstract

A biocompatible surface-functionalized nanoparticle was designed to sense phosphatidylserine exposed on apoptotic cells. We conjugated synthetic artificial phosphatidylserine binding ligands in a multivalent fashion onto magnetofluorescent nanoparticles. Our results show that (1) the synthetic nanoparticles bind to apoptotic cells, (2) there is excellent correlation with annexin V staining by microscopy, and (3) FACS analysis with nanoparticles allows the measurement of therapeutic apoptosis induction. The described nanomaterials should be useful for a variety of biomedical applications including in vivo imaging of apoptosis.

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ApoptosisBiosensing TechniquesFlow CytometryFluorescenceFluorescent DyesHumansJurkat CellsMolecular StructureNanostructuresNanotechnologyJournal ArticleResearch Support, N.I.H., Extramural

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BibTeXRIS

Luisa Quinti, Ralph Weissleder, Ching-Hsuan Tung. 2006. A fluorescent nanosensor for apoptotic cells.. https://doi.org/10.1021/nl0524694

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Apoptosis↗
PubMed2026

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