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PubMed · 16522050

Single molecule nanometronome.

Chittanon Buranachai·Sean A McKinney·Taekjip Ha
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Abstract

We constructed a DNA-based nanomechanical device called the nanometronome. Our device is made by introducing complementary single-stranded overhangs at the two arms of the DNA four-way junction. The ticking rates of this stochastic metronome depend on ion concentrations and can be changed by a set of DNA-based switches to deactivate/reactivate the sticky end. Since the device displays clearly distinguishable responses even with a single base pair difference, it may lead to a single molecule sensor of minute sequence differences of a target DNA.

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DNAFluorescence Resonance Energy TransferNanostructuresNanotechnologyNucleic Acid ConformationStochastic ProcessesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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Chittanon Buranachai, Sean A McKinney, Taekjip Ha. 2006. Single molecule nanometronome.. https://doi.org/10.1021/nl052492p

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