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[Factor X deficiency associated with multiple myeloma].

Luis González-Domínguez·José Manuel Cerqueiro-González·María José Fombella-Posada·Francisco Terrón-Pérez
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Factor X DeficiencyHumansMaleMiddle AgedMultiple MyelomaCase ReportsLetterReview

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Luis González-Domínguez, José Manuel Cerqueiro-González, María José Fombella-Posada, Francisco Terrón-Pérez. 2006-03-04. [Factor X deficiency associated with multiple myeloma].. https://doi.org/10.1157/13085487

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PubMed1985

Factor X Padua: a 'new' congenital factor X abnormality with a defect only in the extrinsic system.

A family with a new factor X defect is reported. The proposita is a 56-year-old female. She is asymptomatic and no consanguinity is present between the parents. The main features of the defect are: prolongation of prothrombin time and derivative tests but normal partial thromboplastin time. Factor X was found to be low (about 25-30% of normal) only if tissue thromboplastins were used in the assay system. Chromogenic substrate S-2222 also yielded decreased factor X levels. However, factor X activity was normal with cephalin and cephalin-RVV mixture. Factor X antigen was normal in three immunological systems (electroimmunoassay, an Elisa method and laser nephelometry). Crossed immunoelectrophoresis and antigen-antibody kinetics recorded in a laser nephelometer failed to show major differences from normal factor X. Both sons of the proposita, the father and other family members showed slightly decreased factor X levels and normal factor X antigen and were considered heterozygous for the abnormality. The toponym factor X Padua is proposed to indicate this peculiar abnormality.

Factor X Deficiency↗