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PubMed · 16533143

Refractory epilepsy: mechanisms and solutions.

Patrick Kwan·Martin J Brodie
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Abstract

Pharmacoresistance remains a major challenge in epilepsy management. The availability of ten new antiepileptic drugs since the late 1980s has not dramatically improved the outcome of refractory epilepsy. This article provides an overview of the contemporary understanding of epilepsy and the limitation of current treatment modalities, discusses putative biological mechanisms of medical intractability and reviews some of the novel strategies under investigation to overcome the challenge of pharmacoresistance.

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AnticonvulsantsDrug Delivery SystemsDrug Resistance, MultipleElectric Stimulation TherapyEpilepsyGenetic TherapyHumansJournal ArticleReview

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Patrick Kwan, Martin J Brodie. 2006. Refractory epilepsy: mechanisms and solutions.. https://doi.org/10.1586/14737175.6.3.397

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